Neutrophils are a type of white blood cell essential for the establishment of an adequate innate immune response against invading pathogens but they also contribute to the development of many acute and chronic inflammatory diseases such as heart attack or rheumatoid athritis, respectively.
There is also evidence for neutrophil involvement in the regulation of the adaptive immunity, the second and specific arm of immune response; however, the precise role of neutrophils in those autoimmune disorders is still unclear.
The focus of my research is to elucidate the mechanisms of neutrophil interactions with lymphatic vessels, migration into lymphoid organs (where adaptive immunity is initiated) and their role in the regulation of the acquired immunity in those acute and chronic pathologies.
Research
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Publications
Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury.
The Journal of Pathology, 2019 (248; 88-102)
Voisin MB, Leoni G, Woodfin A, Loumagne L, Patel NS, Di Paola R, Cuzzocrea S, Thiemermann C, Perretti M and Nourshargh S