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Neutrophils are a type of white blood cell essential for the establishment of an adequate innate immune response against invading pathogens but they also contribute to the development of many acute and chronic inflammatory diseases such as heart attack or rheumatoid athritis, respectively.

There is also evidence for neutrophil involvement in the regulation of the adaptive immunity, the second and specific arm of immune response; however, the precise role of neutrophils in those autoimmune disorders is still unclear. 

The focus of my research is to elucidate the mechanisms of neutrophil interactions with lymphatic vessels, migration into lymphoid organs (where adaptive immunity is initiated) and their role in the regulation of the acquired immunity in those acute and chronic pathologies. 



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Dr. Mathieu-Benoit Voisin

Group Leader


Julia Jeanette Dielesen

PhD Student


Dr Jonathon Coates

Postdoctoral Researcher

Past member


Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury.

The Journal of Pathology, 2019 (248; 88-102)

Voisin MB, Leoni G, Woodfin A, Loumagne L, Patel NS, Di Paola R, Cuzzocrea S, Thiemermann C, Perretti M and Nourshargh S

Neutrophil trafficking to lymphoid tissues: physiological and pathological implications.

The Journal of Pathology, 2019 (247; 662-671)

Voisin MB, Nourshargh S.

Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation.

Scientific Reports, 2017 (7)

Arokiasamy S, Zakian C, Dilliway J, Wang W, Nourshargh S and Voisin MB

Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF.

Journal of Experimental Medicine, 2014 (211; 1307-14)

Finsterbusch M, Voisin MB, Beyrau M, Williams TJ and Nourshargh S

Neutrophil transmigration: emergence of an adhesive cascade within venular walls.

Journal of Innate Immunity, 2013 (5; 336-47)

Voisin MB and Nourshargh S

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.

Journal of Experimental Medicine, 2012 (209; 1219-34)

Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D and Nourshargh S

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.

Nature Immunology, 2011 (12; 761-9)

Woodfin A, Voisin MB, Beyrau M, Colom B, Caille D, Diapouli FM, Nash GB, Chavakis T, Albelda SM, Rainger GE, Meda P, Imhof BA and Nourshargh S

Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.

American Journal of Pathology, 2010 (176; 482-95)

Voisin MB, Pröbstl D and Nourshargh S

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