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Neutrophils are a type of white blood cell essential for the establishment of an adequate innate immune response against invading pathogens but they also contribute to the development of many acute and chronic inflammatory diseases such as heart attack or rheumatoid athritis, respectively.

There is also evidence for neutrophil involvement in the regulation of the adaptive immunity, the second and specific arm of immune response; however, the precise role of neutrophils in those autoimmune disorders is still unclear. 

The focus of my research is to elucidate the mechanisms of neutrophil interactions with lymphatic vessels, migration into lymphoid organs (where adaptive immunity is initiated) and their role in the regulation of the acquired immunity in those acute and chronic pathologies. 



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Dr. Mathieu-Benoit Voisin

Group Leader


Dr Samanta Arokiasamy

PhD student

Past member

Julia Jeanette Dielesen

PhD Student


Dr Jonathon Coates

Postdoctoral Researcher

Past member


Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues


Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L, Golding M, Blacksell IA, Giblin MJ, Jaworska E, Bishop CL, Voisin MB, Gaston-Massuet C, Fossati-Jimack L, Pitzalis C, Cooper D, Nightingale TD, Lopez-Otin C, Lewis MJ, Nourshargh S

Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia

Proc Natl Acad Sci USA

Caxaria S, Bharde S, Fuller AM, Evans R, Thomas B, Celik P, Dell'Accio F, Yona S, Gilroy D, Voisin MB, Wood JN, Sikandar S

Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner.


Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin-Williams SN, Voisin MB, Hussain MT, Law HL, Niki T, Hirashima M, Bombardieri M, Pitzalis C, Tiwari A, Nash GB, Norling LV, Cooper D

Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A

Nature Comm

Joulia R, Guerrero-Fonseca IM, Girbl T, Coates JA, Stein M, Vázquez-Martínez L, Lynam E, Whiteford J, Schnoor M, Voehringer D, Roers A, Nourshargh S, Voisin MB

Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage


Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin MB, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T, Nourshargh S

Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation


Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Voisin MB, Boulanger CM, Kubota Y, Muller WA, Tooze SA, Nightingale TD, Collinson L, Perretti M, Aksoy E, Nourshargh S.

Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibo

Front Immunol

Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS, Nissim A

Local microvascular leakage promotes trafficking of activated neutrophils to remote organs

J Clin Invest

Owen-Woods C, Joulia R, Barkaway A, Rolas L, Ma B, Nottebaum AF, Arkill KP, Stein M, Girbl T, Golding M, Bates DO, Vestweber D, Voisin MB, Nourshargh S

Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury.

The Journal of Pathology, 2019 (248; 88-102)

Voisin MB, Leoni G, Woodfin A, Loumagne L, Patel NS, Di Paola R, Cuzzocrea S, Thiemermann C, Perretti M and Nourshargh S

Neutrophil trafficking to lymphoid tissues: physiological and pathological implications.

The Journal of Pathology, 2019 (247; 662-671)

Voisin MB, Nourshargh S.

Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis


Girbl T, Lenn T, Perez L, Rolas L, Barkaway A, Thiriot A, Del Fresno C, Lynam E, Hub E, Thelen M, Graham G, Alon R, Sancho D, von Andrian UH, Voisin MB, Rot A, Nourshargh S.

Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation.

Scientific Reports, 2017 (7)

Arokiasamy S, Zakian C, Dilliway J, Wang W, Nourshargh S and Voisin MB

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