Dr Dufton's research centres on the adaptability and plasticity of blood vessels, and particularly the cells that line them, termed endothelial cells are fundamental to both vascular and tissue development, homeostasis and disease pathogenesis. He aims to understand the molecular mechanisms that give rise to disease-associated endothelial phenotypes, such as endothelial-to-mesenchymal transition (EndMT), in models of inflammation and fibrosis.
Neil has a keen interest communicating his research through art and public engagement projects. These include an interactive game about cell specialisation, I Cell, working with animator (Genetic Moo) to involve participants in Battle of Blister (part of a Wellcome Large arts grant) and knitting blood vessels (Blood Lines). Neil also produces Sciart and has had his images displayed in the National Geographic, the cover of the Journal of Histopathology and has two of his illustrations curated by the Wellcome Image Collection.