Heart disease is one of the main causes of death in the UK and worldwide. At present no widely available, restorative option exists therefore new strategies are required to identify a safe and efficient way of treating heart failure.
In recent years, stem cells have emerged as a potentially valuable tool for the repair of damaged hearts. In particular a breakthrough discovery, which identified that stem cells could be generated from a patient's own skin cells, termed induced pluripotent stem cells (iPSCs). iPSCs have gained increasing recognition given their ability to generate new, patient-specific, cardiac muscle cells, which when delivered into damaged hearts improve cardiac function.
The focus of Dr Lewis-McDougall's research aims to understand the influence of donor age/disease on iPSC potential, identify the optimal iPSC progeny for cardiac repair and investigate extracellular vesicles as mediators of cardiac repair.
Dr Sammy El Mansi
Dr Caroline Anderson
Dr Maryna Samus
Dr Esteban Ortega
Dr Mohsin Hussain