Neutrophils are a type of white blood cell essential for the establishment of an adequate innate immune response against invading pathogens but they also contribute to the development of many acute and chronic inflammatory diseases such as heart attack or rheumatoid athritis, respectively.
There is also evidence for neutrophil involvement in the regulation of the adaptive immunity, the second and specific arm of immune response; however, the precise role of neutrophils in those autoimmune disorders is still unclear.
The focus of my research is to elucidate the mechanisms of neutrophil interactions with lymphatic vessels, migration into lymphoid organs (where adaptive immunity is initiated) and their role in the regulation of the acquired immunity in those acute and chronic pathologies.
I am interested in immune cell biology, particularly how immune cells are capable of performing such wide ranging functions and adapting to different environments. I completed my PhD at the University of Sheffield investigating the existence of macrophage subtypes in Drosophila. I am currently exploring neutrophils and T-cell interactions in cardiovascular & inflammatory diseases.
Outside of the lab I enjoy photography, a cocktail or four, and guitars, climbing and adrenaline fuelled adventures.
Dr Jonathon Coates
I am interested in haematopoiesis and the bone marrow microenvironment. ACKR1 is an exciting molecule in this context, because it is expressed by erythroid cells that make up one third of the bone marrow cellularity.
I am interested in the immunological consequences of a single nucleotide polymorphism within the ACKR1 gene which is prevalent in African populations.
My research aims to understand the role of atypical chemokine receptors in the alteration of the immune system and subsequent impacts on tumour growth and progression.
Dr Julia Gutjahr
Dr Caroline Anderson
Dr Maryna Samus
My PhD is focused on investigating the expression and function of ACKR4 in the heart. My work aims to characterise localisation and cell type expression of ACKR4, as well as its effect on heart function and health.
Physician Surgeon (UNAM, Mexico); MSc. Regenerative Medicine (QMUL, London)
Exosomes and biomaterials for heart failure. Other interests: Immunology, 3D printing, patient specific implants & biofabrication.
Dr Esteban Ortega
I am a Cardiology SpR based at Barts Hospital and am currently undertaking a PhD investigating the efficacy of stem-cell therapy in patients with DCM.
Dr Mohsin Hussain
Dr Samantha Arokiasamy
Dr Christian Zakian
Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury.
The Journal of Pathology, 2019 (248; 88-102)
Voisin MB, Leoni G, Woodfin A, Loumagne L, Patel NS, Di Paola R, Cuzzocrea S, Thiemermann C, Perretti M and Nourshargh S
Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation.
Scientific Reports, 2017 (7)
Arokiasamy S, Zakian C, Dilliway J, Wang W, Nourshargh S and Voisin MB
Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF.
Journal of Experimental Medicine, 2014 (211; 1307-14)
Finsterbusch M, Voisin MB, Beyrau M, Williams TJ and Nourshargh S
Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.
Journal of Experimental Medicine, 2012 (209; 1219-34)
Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D and Nourshargh S
The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.
Nature Immunology, 2011 (12; 761-9)
Woodfin A, Voisin MB, Beyrau M, Colom B, Caille D, Diapouli FM, Nash GB, Chavakis T, Albelda SM, Rainger GE, Meda P, Imhof BA and Nourshargh S
Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.
American Journal of Pathology, 2010 (176; 482-95)
Voisin MB, Pröbstl D and Nourshargh S
You can see our full publication list here. If you cannot access any of our papers, please do contact us, we would be happy to share a copy.