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The experimental work in our lab aims to answer intensely burning as well as long-term smouldering questions in chemokine biology to bring new understanding of mechanisms in immunity and disease pathogenesis. From their humble beginnings on the fringes of experimental research, known initially as a couple of leukocyte chemoattractants, chemokines became one of the largest families of coherently functioning, intercellular signals, involved in a mutitude of cellular processes and studied now by the cutting edge mainstream molecular science and medicine. Chemokines are now known as versatile units of inter-cellular communications, the building blocks of a universal cell language, "chemokinese", the cell Esperanto.

Chemokine activities contribute to almost every aspect of our biological existence, starting with the moment of our conception, through months of intrauterine confinement; protecting us during the years of growth, health and wellbeing, only to push us later, along countless avenues of debilitating diseases, ultimately into the grave. It is impossible to encompass the breadths of all chemokines' activities and account for their multifaceted roles, therefore the experimental work in our lab lately focuses on the biology of atypical chemokine receptors, ACKR1 and ACKR4, in particular.

These unusual receptors are able to modulate the availability and function of their cognate chemokines and achieve this in particularly unpredictable but powerful ways, thus importantly modifying chemokine-encoded messages. 

Our lab is generously supported by the Wellcome Trust, Versus Arthritis and the British Heart Foundation.



Antal Rot

Antal Rot

Group Leader

Dr Julia Gutjahr

Dr Julia Gutjahr

Postdoctoral Researcher

Past member
Dr Neil Dufton

Dr Neil Dufton

Lecturer (associate member)

Past member
Elin Hub

Elin Hub

Lab Manager

Dr Katharina Artinger

Dr Katharina Artinger

Visiting Research Fellow

Past member
Dr Maryna Samus

Dr Maryna Samus

Postdoctoral Researcher

Stefan Russo

Stefan Russo

PhD Student

Past member


Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1

Cell Stem Cell. 2022 Jul 7;29(7):1013-1015. doi: 10.1016/j.stem.2021.11.010.

Rot A, Gutjahr JC, Biswas A, Aslani M, Hub E, Thiriot A, Andrian UHv, Megens RTA, Weber C, Duchene J

Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp

Cell Rep. 2021 Jul 13;36(2):109346. doi: 10.1016/j.celrep.2021.109346.

Werth K, Hub E, Gutjahr JC, Bosjnak B, Zheng X, Bubke A, Russo S, Rot A, Förster R

The dimeric form of CXCL12 binds to atypical chemokine receptor 1

Science Signaling 17 Aug 2021: Vol. 14, Issue 696, eabc9012. DOI: 10.1126/scisignal.abc9012

Julia C. Gutjahr, Kyler S. Crawford, Davin R. Jensen, Prachi Naik, Francis C. Peterson, Guerric P. B. Samson, Daniel F. Legler, Johan Duchene, Christopher T. Veldkamp, Antal Rot, Brian F. Volkman

Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.

Nature Immunology, 2017 (18; 753-761).

Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K, Artinger K, Eller K, Caamaño J, Rülicke T, Moss P, Megens RTA, von Andrian UH, Hidalgo A, Weber C and Rot A

New nomenclature for atypical chemokine receptors.

Nature Immunology, 2014 (15; 207-8)

Bachelerie F, Graham GJ2 Locati M, Mantovani A, Murphy PM, Nibbs R, Rot A, Sozzani S and Thelen M

The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes.

Nature Immunology, 2014 (15; 623-30)

Ulvmar MH, Werth K, Braun A, Kelay P, Hub E, Eller K, Chan L, Lucas B, Novitzky-Basso I, Nakamura K, Rülicke T, Nibbs RJ, Worbs T, Förster R and Rot A

The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity.

Nature Immunology, 2009 (10; 101-8)

Pruenster M, Mudde L, Bombosi P, Dimitrova S, Zsak M, Middleton J, Richmond A, Graham GJ, Segerer S, Nibbs RJB, and Rot A

CCR7 and its ligands: balancing immunity and tolerance.

Nature Reviews Immunology, 2008 (8; 362-71)

Förster R, Davalos-Misslitz AC and Rot A

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity.

Nature Immunology, 2008 (9; 1261-9)

Rubic T, Lametschwandtner G, Jost S, Hinteregger S, Kund J, Carballido-Perrig N, Schwärzler C, Junt T, Voshol H, Meingassner JG, Mao X, Werner G, Rot A and Carballido JM

CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells.

Journal of Experimental Medicine, 2007 (204; 735-45)

Schneider MA, Meingassner JG, Lipp M, Moore HD and Rot A

Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells.

Nature Immunology, 2005 (6; 1038-46)

Dar A, Goichberg P, Shinder V, Kalinkovich A, Kollet O, Netzer N, Margalit R, Zsak M, Nagler A, Hardan I, Resnick I, Rot A and Lapidot T

Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells.

Annual Review of Immunology, 2004 (22; 891-928)

Rot A and von Andrian UH

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