Rot_GroupHeader_edited.png

Rot Lab

 

The experimental work in our lab aims to answer intensely burning as well as long-term smouldering questions in chemokine biology to bring new understanding of mechanisms in immunity and disease pathogenesis. From their humble beginnings on the fringes of experimental research, known initially as a couple of leukocyte chemoattractants, chemokines became one of the largest families of coherently functioning, intercellular signals, involved in a mutitude of cellular processes and studied now by the cutting edge mainstream molecular science and medicine. Chemokines are now known as versatile units of inter-cellular communications, the building blocks of a universal cell language, "chemokinese", the cell Esperanto.


Chemokine activities contribute to almost every aspect of our biological existence, starting with the moment of our conception, through months of intrauterine confinement; protecting us during the years of growth, health and wellbeing, only to push us later, along countless avenues of debilitating diseases, ultimately into the grave. It is impossible to encompass the breadths of all chemokines' activities and account for their multifaceted roles, therefore the experimental work in our lab lately focuses on the biology of atypical chemokine receptors, ACKR1 and ACKR4, in particular.

These unusual receptors are able to modulate the availability and function of their cognate chemokines and achieve this in particularly unpredictable but powerful ways, thus importantly modifying chemokine-encoded messages. 

Our lab is generously supported by the Wellcome Trust, Versus Arthritis and the British Heart Foundation.

"I am a human, and nothing human is alien to me"

- Terence

"I am a pathologist, and no pathomechanism is alien to me, especially if it involves chemokines"

- Antal

RESEARCH OVERVIEW

Antal Rot_edited.jpg

Antal Rot

Group Leader

ElinHub_Profile.jpeg

Elin Hub

Lab Manager

GROUP MEMBERS

I am interested in haematopoiesis and the bone marrow microenvironment. ACKR1 is an exciting molecule in this context, because it is expressed by erythroid cells that make up one third of the bone marrow cellularity.

Portrtraitfoto_Gutjahr_edited.jpg

Dr Julia Gutjahr

Postdoctoral Researcher

I am interested in the immunological consequences of a single nucleotide polymorphism within the ACKR1 gene which is prevalent in African populations.

Dr Caroline Anderson

Postdoctoral Researcher

Dr Maryna Samus

Postdoctoral Researcher

Caroline-Anderson_Profile.jpg

My research aims to understand the role of atypical chemokine receptors in the alteration of the immune system and subsequent impacts on tumour growth and progression.

Maryna-Samus_profile.jpg

My PhD is focused on investigating the expression and function of ACKR4 in the heart. My work aims to characterise localisation and cell type expression of ACKR4, as well as its effect on heart function and health.

Stefan_profile_edited.jpg

Stefan Russo

PhD Student

ND_profile_2.jpg

I am a Cardiology SpR based at Barts Hospital and am currently undertaking a PhD investigating the efficacy of stem-cell therapy in patients with DCM.

bad-profile-pic-2-768x768_edited.jpg

Dr Mohsin Hussain

PhD Student

GROUP ALUMNI

Fields of research interest:

Tissue engineering, stem cell therapy

 

Research:

Biomaterials design for epicardial placement of mesenchymal stem cells for the treatment of myocardial infarction 

Yaqi You.jpg

Yaqi You

PhD Student

Graduate of The University of Aberdeen (BSc Sport & Exercise Science) and Queen Mary University of London (MRes Inflammation) with an interest in the role of M2-like macrophages in cardiac repair after myocardial infarction.

Mihai_edited.jpg

GROUP ALUMNI

Mihai Podaru

PhD Student

RECENT PUBLICATIONS

The dimeric form of CXCL12 binds to atypical chemokine receptor 1

Science Signaling 17 Aug 2021: Vol. 14, Issue 696, eabc9012. DOI: 10.1126/scisignal.abc9012

Julia C. Gutjahr, Kyler S. Crawford, Davin R. Jensen, Prachi Naik, Francis C. Peterson, Guerric P. B. Samson, Daniel F. Legler, Johan Duchene, Christopher T. Veldkamp, Antal Rot, Brian F. Volkman

Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp

Cell Rep. 2021 Jul 13;36(2):109346. doi: 10.1016/j.celrep.2021.109346.

Werth K, Hub E, Gutjahr JC, Bosjnak B, Zheng X, Bubke A, Russo S, Rot A, Förster R

Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.

Nature Immunology, 2017 (18; 753-761).

Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K, Artinger K, Eller K, Caamaño J, Rülicke T, Moss P, Megens RTA, von Andrian UH, Hidalgo A, Weber C and Rot A

The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes.

Nature Immunology, 2014 (15; 623-30)

Ulvmar MH, Werth K, Braun A, Kelay P, Hub E, Eller K, Chan L, Lucas B, Novitzky-Basso I, Nakamura K, Rülicke T, Nibbs RJ, Worbs T, Förster R and Rot A

New nomenclature for atypical chemokine receptors.

Nature Immunology, 2014 (15; 207-8)

Bachelerie F, Graham GJ2 Locati M, Mantovani A, Murphy PM, Nibbs R, Rot A, Sozzani S and Thelen M

The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity.

Nature Immunology, 2009 (10; 101-8)

Pruenster M, Mudde L, Bombosi P, Dimitrova S, Zsak M, Middleton J, Richmond A, Graham GJ, Segerer S, Nibbs RJB, and Rot A

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity.

Nature Immunology, 2008 (9; 1261-9)

Rubic T, Lametschwandtner G, Jost S, Hinteregger S, Kund J, Carballido-Perrig N, Schwärzler C, Junt T, Voshol H, Meingassner JG, Mao X, Werner G, Rot A and Carballido JM

CCR7 and its ligands: balancing immunity and tolerance.

Nature Reviews Immunology, 2008 (8; 362-71)

Förster R, Davalos-Misslitz AC and Rot A

CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells.

Journal of Experimental Medicine, 2007 (204; 735-45)

Schneider MA, Meingassner JG, Lipp M, Moore HD and Rot A

Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells.

Nature Immunology, 2005 (6; 1038-46)

Dar A, Goichberg P, Shinder V, Kalinkovich A, Kollet O, Netzer N, Margalit R, Zsak M, Nagler A, Hardan I, Resnick I, Rot A and Lapidot T

Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells.

Annual Review of Immunology, 2004 (22; 891-928)

Rot A and von Andrian UH

The β-Chemokine Receptor D6 Is Expressed by Lymphatic Endothelium and a Subset of Vascular Tumors.

American Journal of Pathololgy, 2001 (158; 867–877)

Nibbs RJB, Kriehuber E, Ponath PD, Parent D, Qin S, Campbell JDM, Henderson A, Kerjaschki D, Maurer D, Graham GJ, and Rot A

You can see our full publication list here. If you cannot access any of our papers, please do contact us, we would be happy to share a copy.

LATEST NEWS

CURRENT PROJECTS

IMAGE GALLERY